Get Absorption and Drug Development: Solubility, Permeability, PDF
By Alex Avdeef
Explains the right way to practice and examine the result of the most recent physicochemical methods
With this e-book as their advisor, readers have entry to the entire present details had to completely examine and safely be sure a compound's pharmaceutical homes and their results on drug absorption. The booklet emphasizes oral absorption, explaining all of the physicochemical equipment used this present day to investigate drug applicants. additionally, the writer presents professional suggestions to aid readers learn the result of their stories so that it will opt for the main promising drug candidates.
This Second Edition has been completely up-to-date and revised, incorporating all of the most recent study findings, tools, and assets, including:
Descriptions and functions of latest PAMPA versions, drawing on greater than thirty papers released by way of the author's learn group
Two new chapters studying permeability and Caco-2/MDCK and permeability and the blood-brain barrier
Expanded details and strategies to aid pKa determination
New examples explaining the remedy of virtually insoluble try out compounds
Additional case reports demonstrating using the newest physicochemical techniques
New, revised, and multiplied database tables in the course of the book
Well over two hundred drawings support readers greater comprehend tricky strategies and supply a visible advisor to complicated approaches. moreover, over 800 references function a gateway to the first literature within the box, facilitating extra learn into all of the subject matters coated within the book.
This Second Edition is usually recommended as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different comparable components of analysis. it's also urged as a supplemental textual content for graduate classes in pharmaceutics.
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Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef